3 How to have Zofran Solution for Injection or Infusion Emetogenic chemotherapy and radiotherapy For patients receiving emetogenic chemotherapy or radiotherapy ondansetron can be given either by intravenous or other routes of administration, however this product is for intravenous use only. (2.4) ( 4 ) Concomitant use of apomorphine. Nausea and Vomiting Adult: PO 8 mg 30 min before chemotherapy, then q8h times 2 more doses Adult/ Child: IV 6 mo-18 y, 0.15 mg/kg or 32 mg infused over 15 min beginning 30 min before start of chemotherapy, followed by 0.15 mg/kg 4 and 8 h after first dose of ondansetron, may also give 8 mg bolus, then 1 mg/h by continuous infusion (max: 32 mg/d), or 32 mg as single dose Ondansetron Injection, USP (2 mg/mL): 2 mL Prefilled disposable single-dose syringe. Ondansetron injection should be clear and colorless. Call your doctor at once if you have: headache with chest pain and severe dizziness, fainting . Local: Injection site reaction (IV: 4%; includes burning sensation at injection site, erythema at injection site, injection site pain) . The dose of Zofran for hyperemesis gravidarum requiring hospitalization is a maximum of 10 milligrams via intravenous therapy (IV) every 8 hours. FDA previously issued a DSC about the ongoing safety review of ondansetron in September 2011. Post-op (do not dilute): Infuse in not less than 30 seconds, preferably over 2-5 mins: 4mg IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs. Order for patient CC reads, "ondansetron 4mg subcutaneously once as loading dose, then infuse subcutaneously at a continuous rate of .5mg/hr with a bolus dose 0.25mg every 30 minutes as needed for nausea/vomiting." Ondansetron solution for injection is available in 2mg/mL vials and 32mg/50mL premixed bags with dextrose 5% . Pediatric Use Pet insurance can be a safety net for you and your pet, helping your pet care budget go further. Nausea and vomiting associated with cancer chemotherapy- 24 mg as a single. Ondansetron Injection Warnings/Precautions: <4 months of age (monitor closely). Dosing will be based on weight. or Intramuscular (I.M.) For patients receiving highly emetogenic chemotherapy, eg. Ondansetron is well absorbed from the gastrointestinal tract and undergoes some first-pass metabolism. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. More common side effects The more common side effects of ondansetron can include: headache. Adults: The recommended adult intravenous dosage of ZOFRAN is three .15-mg/kg doses up to a maximum of 16 mg per dose. Ondansetron injection is used to prevent nausea and vomiting caused by cancer medicines (chemotherapy or radiation), including high-dose cisplatin. Indications and dose Moderately emetogenic chemotherapy or radiotherapy By mouth Adult Initially 8 mg, dose to be taken 1-2 hours before treatment, then 8 mg every 12 hours for up to 5 days. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Ondansetron side effects. Ondansetron Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. Adults: The recommended adult intravenous dosage of ondansetron is three 0.15 mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY (12.2)]. Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose. Before using Ondansetron Injection, inform your doctor about your current list of medications, over the counter products (e.g. The recommended adult oral dosage of ondansetron hydrochloride tablet is 24 mg given as three 8 mg tablets administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin 50 mg/m2. the updated label will state that ondansetron can continue to be used in adults and children with chemotherapy-induced nausea and vomiting at the lower intravenous dose recommended in the drug label, a dose of 0.15 mg/kg administered every 4 hours for three doses; however, no single intravenous dose should exceed 16 mg. information from the new AUC from a 16-mg US Brand Name. Ondansetron may cause serious side effects. The dosage of ondansetron for cats and dogs can vary on the basis of the reason for the prescription. If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents. The administration duration also varies depending on the condition to be treated, the response and any side effects noted. Ondansetron Injection, USP (2 mg/mL): 2 mL single dose vial and 20 mL multiple dose vial. Using it for only the summer months should be no problem at all. ( 3) CONTRAINDICATIONS Patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Serotonin syndrome reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs including SSRIs, SNRIs, MAO inhibitors, lithium, tramadol . Not a substitute for nasogastric suction in gastric or intestinal peristalsis. The general doggy dosage is 1 mg/ per pound, so that's what your vet has prescribed - most people tend to go too low on the dosage. Ondansetron Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. . It can also cause other side effects. Ondansetron injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. ).Some health conditions may make you more susceptible to the side-effects of the drug. heart rate irregularities (including ventricular and supraventricular tachycardia, premature ventricular contractions, and atrial fibrillation) slow heart rate. Follow your doctor's dosing instructions very carefully. ondansetron 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen 00078067919 zofran odt 4 mg tablet 08/30/2017 12/31/2019 j9214 injection, interferon, alfa-2b, recombinant, 1 million units 00085111001 numbness and tingling. Chemotherapy that causes moderate nausea and vomiting: 8 mg dose taken 30 minutes before the start of chemotherapy, with another 8 mg dose taken 8 hours after the first dose. Intravenous dosage Adults 0.15 mg/kg (150 mcg/kg) IV infused over 15 minutes beginning 30 minutes prior to the initiation of emetogenic chemotherapy. In dogs, the usual dose is 0.05 to 0.5 mg per pound (0.1 to 1.0 mg/kg) orally every 12 to 24 hours. In cats, the usual dose is 0.11 mg per pound (0.22 mg/kg) every 8 to 12 hours. No single dose should exceed 16 mg/dose IV. Administration: Each 1 mL of aqueous solution in the 2-mL single-dose vial contains 2 mg of ondansetron as the hydrochloride dihydrate; 9.0 mg of sodium chloride, USP; and 0.5 mg of citric acid The recommended adult intravenous dosage of ZOFRAN is three .15-mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY]. Oral: Prevention of post-op nausea and vomiting- 16 mg 1 hour before anesthesia. Additional doses may be given 4 hours after the first dose of ondansetron and 8 hours after the first dose of ondansetron, if needed. Mean bioavailability in healthy subjects, following administration of a single 8-mg tablet, is approximately 56%. The nasal cavity can be a potential alternative route. ), allergies, pre-existing diseases, and current health conditions (e.g. Multiday, single-dose administration of a 24 mg dosage has not been studied. ZOFRAN Injection Dosage Intravenous Infusion Rate ; Adults > 12 yrs ; 4 mg x 1 : over 2 - 5 min : Pediatrics (> 40 kg) 4 mg x 1 ; over 2 - 5 min : Pediatrics ( 40 kg) 0.1 mg/kg x 1 : over 2 - 5 min In patients with severe hepatic impairment, a total daily dose of 8 mg should not be exceeded. The recommended dosage of ondansetron is generally in the range of 0.05 to 0.5mg per pound of the body weight of the pet . Children 1 month to 17 years old: Children and adolescents will receive ondansetron injections instead of Zofran tablets Zofran dosage for children Ondansetron is used in children as young as 6 months old to prevent nausea provoked by cancer chemotherapy or as young as 1 month old to prevent postoperative nausea. Doses of Zofran Solution for Injection or Infusion contains sodium citrate and sodium chloride. . 4 CONTRAINDICATIONS Ondansetron injection is contraindicated for patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. More typical pregnancy nausea is managed by a much . Read more Did you find an answer to your question? ZOFRAN Injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. ( 4, 7.2) WARNINGS AND PRECAUTIONS Ondansetron systemic exposure does not increase proportionately to dose. ( 3 ) CONTRAINDICATIONS Patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Common side effects of Onset 2 MG Injection are constipation, headache and dizziness. If you are on a low sodium diet, speak to your doctor, nurse or pharmacist before you have Zofran injection. By rectum Adult ( 4) Concomitant use of apomorphine. Caution: Dilution of Ondansetron Injection is required in adult and pediatric patients prior to administration. Maximum dose: 16 mg (per dose) Comments: The injection formulation should be diluted in 50 mL prior to IV administration. Prevention of Postoperative Nausea and/or Vomiting vitamins, herbal supplements, etc. Injection-site pain (4%) . The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is 0.15 mg/kg per dose for 3 doses (maximum of 16 mg per dose). Ondansetron Injection, USP 2 mg per mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multi-dose vial. Injection: 5 mg/2 mL (2.5 mg/mL) or 10 mg/4 mL (2.5 mg/mL) as a clear, colorless sterile solution in a single-dose vial. Ondansetron is not a drug that stimulates gastric or intestinal peristalsis; should not be used instead of nasogastric suction. elevated liver function test results. 16 HOW SUPPLIED/STORAGE AND HANDLING Ondansetron Injection, USP, 2 mg/mL, is supplied as follows: Unit of Sale Concentration NDC 0409-4755-03 Carton of 25 2 mL Single-dose Vials 4 mg/2 mL (2 mg/mL) NDC 0409-4759-01 Carton of 1 20 mL Multiple-dose Vials 40 pregnancy, upcoming surgery, etc. Includes Ondansetron indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Zofran; Descriptions. This medicine starts to work in 30 minutes. Dosage may be repeated twice, administered 4 and 8 hours after the initial dose. It works by blocking a natural substance called serotonin in the brain that causes nausea and vomiting. Ondansetron Injection, USP, 2 mg/mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multiple-dose vial. injection-site pain. Get emergency medical help if you have any of these signs of an allergic reaction: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Drug information provided by: IBM Micromedex. Ondansetron orally disintegrating tablet may cause drowsiness. Ondansetron Injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. Our scientific content is evidence-based, scientifically balanced and . A second and third dose of ondansetron are sometimes given 4 hours and 8 hours after the first dose. I had a dog who needed it a good 8 months or more of every year and it never caused any trouble. Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. 3 DOSAGE FORMS AND STRENGTHS Ondansetron Injection, USP, 2 mg/mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multiple-dose vial. Yes No 4 CONTRAINDICATIONS Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. SLIDESHOW dosage of Ondansetron for pediatric patients (2 to 12 years of age) is a single .1-mg/kg dose for pediatric patients weighing 40 kg or less, or a single 4 mg dose for pediatric patients weighing more than 40 kg. Onset 2 MG Injection is an antiemetic medicine used to treat and prevent nausea and vomiting caused by surgery, cancer medicines (chemotherapy) or radiation therapy. The intravenous dose is 0.05 to 0.1 mg per pound (0.1 to 0.2 mg/kg). Injection: The recommended I.V. Learn how to store and discard medical supplies safely.To prevent or treat nausea after surgery, a single dose of ondansetron may be given undiluted into a muscle or vein (IV) shortly before the start of surgery, during surgery, or after surgery by a health care professional.Dosage is based on your weight, medical condition, and response to . Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Postoperative: Oral:-Recommended dose: 16 mg orally 1 hour before the induction of anesthesia . Read More May mask progressive ileus and/or gastric distention. Hope it works well for your Bostie! Ondansetron Injection is approved for patients aged 6 months and older. Dosage Forms And Strengths. If you are using the premixed bags, after removing the bag from the outer wrapper, check for small leaks by squeezing the container firmly. cold sensation. This medicine is also used to prevent and treat nausea and vomiting that may happen after surgery. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. and in patients taking other medicinal products (e.g., ondansetron) or with other medical conditions known to prolong the QT interval . Sterile Injection for Intravenous (I.V.) A dose of 1 mg/kg OND (Zofran injection, 2 mg/mL) was administered to male Sprague-Dawley rats intravenously or intranasally. What is the dosage of Ondansetron? The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is .15mg/kg per dose for 3 doses (maximum of 16 mg per dose). Or, may use 4mg IM undiluted as a single injection. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. highdose cisplatin, ondansetron may be administered as a single 8mg intravenous or intramuscular dose by slow intravenous injection in not less than 30 seconds, or intramuscular injection, immediately before chemotherapy. The peak plasma level of OND was attained within 10 min after application to the nasal mucosa of the rat. Adults: The recommended adult intravenous dosage of Ondansetron is three .15-mg/kg doses up to a maximum of 16 mg per dose. Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery. WHAT IS Ondansetron? The dose range of ondansetron solution for injection or infusion is 8-32 mg a day and selected as shown below. Severe hepatic dysfunction: max 8mg/day. The plasma concentration-time profiles for nasal . Ondansetron is a specific 5HT 3 -receptor antagonist which blocks 5HT 3 receptors in the gastro-intestinal tract and in the CNS. Electrolyte abnormalities, CHF, bradyarrhythmias, concomitant drugs that prolong QT: monitor ECG. Ondansetron HCl is a white to off-white powder that is soluble in water and normal saline. (4, 7.2) WARNINGS AND PRECAUTIONS Congenital long QT syndrome: avoid. Take the. Ondansetron injection for the treatment of post-operative nausea and vomiting has been reported to cause drowsiness or sedation in 8% of patients vs. 7% of those using a placebo (an inactive . Typical dosing for Zofran (ondansetron) Adults: Chemotherapy that causes severe nausea and vomiting: A single 24 mg dose taken 30 minutes before the start of a single-day highly vomit-inducing chemotherapy. This means that Zofran injection contains 7 mg of sodium per 4 mg dose. 1.2 Prevention of Postoperative Nausea and/or Vomiting Ondansetron Injection is approved for patients aged 6 months and older. Other side effects of Ondansetron include: Cardiac. 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Content is evidence-based, scientifically balanced and Sprague-Dawley rats intravenously or intranasally is not a for. Medicinal products ( e.g is a white to off-white powder that is soluble in and. In patients taking other medicinal products ( e.g -receptor antagonist which blocks 5HT 3 receptors the! Vomiting caused by chemotherapy, ondansetron is well absorbed from the gastrointestinal tract and in ondansetron injection dosage taking other products! Needed it a good 8 months or more of every year and it never caused trouble. Is approved for patients aged 6 months and older and dogs can on! The start of chemotherapy the drug 8 months or more of every year and it never caused any....
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