Some of the information, including information about funding for cancer drugs, does not apply . Cyclophosphamide is also an immunosuppressant, which means that it suppresses your body's immune or defence system. A similar regimen may be used for high-dose cyclophosphamide therapy. The total leukocyte count is a good . Many other regimens of intravenous and oral cyclophosphamide have been reported. low levels of a type of white blood cell called neutrophils. dehydration. This information is about the oral (by mouth) formulation. Cyclophosphamide The ARA supports and educates members and other practitioners in the musculoskeletal field to enable provision of best possible management for patients. Cyclophosphamide is a potent drug that is primarily used in the treatment of cancer.It belongs to the class of cytotoxic drugs called alkylating agents; these interfere with the growth and replication of malignant cells.. Cyclophosphamide is found to be useful in the treatment of some skin diseases, particularly autoimmune skin diseases or those associated with some sort of immune disorder. It is not intended to be medical advice. Positive prognostic effects of cyclophosphamide pulse therapy in ICU treated patients suffering from severe respiratory failure due to pulmonary manifestations of both SSc and ANCA-associated-vasculitis were observed. 28. Cyclophosphamide (pronounced sigh-clo-fos-fah-mide) is a type of chemotherapy. Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis. The dose of cyclophosphamide that saturates its activation varies among patients, but is in the range used for high-dose clinical indications. Anaphylactic reactions including death have been reported with cyclophosphamide. Cyclophosphamide is usually used in combination with other drugs. For high-dose ifosfamide therapy, a mesna dose of 20% of the ifosfamide dosage IV has been administered 15 minutes before ifosfamide administration and then every 3 hours for 3 to 6 doses. Identify the mechanism of action and administration of cyclophosphamide. Store cyclophosphamide PO solution in refrigerator at 2-8 C (36-46 F), and use within 14 d. Intravenous. The mechanism of action is thought to involve cross-linking of tumor cell DNA. Urinary Outflow Obstruction Cyclophosphamide also possesses potent immunosuppressive activity. Hodgkin lymphoma. Cyclophosphamide/Cytoxan/Neosar Intravenous Inj Pwd F/Sol: 1g, 2g, 500mg DOSAGE & INDICATIONS For the treatment of acute lymphocytic leukemia (ALL). Many other regimens of intravenous and oral cyclophosphamide have been reported. Cyclophosphamide is a nitrogen mustard that exerts its anti-neoplastic effects through alkylation. An antiemetic medication may be prescribed to be given before the drug. Chronic granulocytic leukemia. Acute monocytic leukemia. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. When people have an autoimmune condition, the body's immune system can mistakenly cause harm to healthy tissues. Cyclophosphamide is a prodrug that must be metabolized to active metabolites in the liver. Because of this, it is sometimes used to treat severe symptoms of conditions such as rheumatoid arthritis. Tell your doctor if any of these symptoms are severe or do not go away: nausea vomiting loss of appetite or weight abdominal pain diarrhea hair loss sores on the mouth or tongue changes in skin color changes in color or growth of finger or toe nails Some side effects can be serious. The armamentarium of therapy in ANCA vasculitis now includes induction with rituximab or cyclophosphamide with glucocorticosteroids. multiple myeloma. Oral cyclophosphamide dosing is usually in the range of 1 mg per kg per day to 5 mg per kg per day for both initial and maintenance dosing. Oral cyclophosphamide dosing is usually in the range of 1mg per kg per dayto 5 mg per kg per day for both initial and maintenance dosing. Breast Cancer 600 mg/m IV with other antineoplastics; dose intensification possible Juvenile Idiopathic Arthritis/Vasculitis (Off-label) 10 mg/kg IV every 2 weeks Lupus Nephritis (Off-Label). Cyclophosphamide was first approved by the U.S. Food and Drug Administration (FDA) in 1959, and is still widely used to treat multiple myeloma, as well as many other types of cancer and autoimmune diseases. Dosages must be adjusted in accord with evidence of antitumor activity and/or leukopenia. It has been used extensively to treat severe manifestations of a variety of autoimmune and inflammatory diseases. Further prognostic and therapeutic data are needed for cyclophosphamide for this indication in order to prevent patients . For the treatment of nodular or diffuse ALL. Cough or sore throat Unusual bleeding or bruising Burning feeling or pain when urinating Pain in the lower back or side Blood in the urine or in the stool Black, tarry stools Trouble breathing or shortness of breath Fast heartbeat Dizziness, confusion, or agitation Yellow eyes or skin Cyclophosphamide Tablets is indicated for the treatment of: malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma multiple myeloma Therefore, Cyclophosphamide Injection should be administered in the morning. The total leukocyte count is a good, objective guide for . Cyclophosphamide is FDA approved to treat several types of cancer, including people who have Hodgkin lymphoma, non-Hodgkin lymphoma, acute and chronic lymphocytic leukemia, acute and chronic myeloid leukemia, myeloma, and mycosis fungoides. Cyclophosphamide / administration & dosage Cyclophosphamide / adverse effects Disease-Free Survival Cyclophosphamide can be given by intravenous (IV, into a vein) infusion or taken orally (by mouth) in a pill or capsule form. However this comes with potential toxicities, including nausea, haemorrhagic cystitis, bladder cancer, bone marrow suppression, increased risk of opportunistic infections, and . Cyclophosphamide Injection is indicated for the treatment of: malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma. PREPARE: Direct: Add 5 mL sterile water for injection or bacteriostatic water for injection (paraben-preserved only) to each 100 mg and shake gently to dissolve. For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking cyclophosphamide. Cyclophosphamide is a prodrug that requires cytochrome P450-mediated activation to 4-hydroxycyclophosphamide. Water intoxication following intravenous low-dose CY is reported rarely to cause life-threatening water intoxication . Cyclophosphamide, although effective alone in susceptible malignancies, is more frequently used concurrently or sequentially with other antineoplastic drugs. Stability - CYC tablets should be stored in covered containers. Total daily mesna dosage is at least 60% of the ifosfamide dosage. Cyclophosphamide . Many other regimens of intravenous and oral cyclophosphamide have been reported. Refrigeration is not necessary, although the drug may be unstable Cyclophosphamide | C7H15Cl2N2O2P | CID 2907 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Adult: Monotherapy or in combination with other antineoplastic agents: Dose and treatment duration or interval are individualised depending on the indication, scheme of combination therapy, or patient condition including the state of bone marrow. Because pulse therapy bears less side effects than oral one we aimed to follow the cyclophosphamide effect on the course of patients with primary glomerulonephritis. Dosages must be adjusted in accord with evidence of antitumor activity and/or leukopenia. Cyclophosphamide is often given alongside other medicines to help treat cancer. Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). The total leukocyte count is a . However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Cyclophosphamide. Talk with your doctor about your specific risk. It belongs to the class of drugs known as alkylating agents, which inhibit DNA and RNA synthesis, causing the death of both dividing and non-dividing tumor cells. Oral cyclophosphamide dosing is usually in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. Cyclophosphamide Mechanism : Cyclophosphamide is bio transformed principally in the liver to active alkylating metabolites by microsomal oxidase system. Cyclophosphamide is a highly potent immunosuppressant that has demonstrated efficacy in inducing and maintaining remission in autoimmune and inflammatory illnesses. Oral cyclophosphamide dosing is usually in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. Many other regimens of intravenous and oral cyclophosphamide have been reported. Cyclophosphamide is indicated in the treatment of: . Prior removal of adrenal gland(s)Toxic effects of cyclophosphamide may be increased, dosage adjustment may be necessary. GRAPHICS. It is a cell cycle phase nonspecific agent. Ask your doctor for ways to lessen these effects. Cyclophosphamide may cause side effects. The total leukocyte count is a good, objective guide for regulating dosage. Cyclophosphamide (CYC), an alkylating agent, is one of the most potent immunosuppressive therapies available. It is generally Cyclophosphamide pulmonary toxicity of cyclophosphamide pulmonary toxicity will be presented here. For treatment of immune disorders, cyclophosphamide is dosed at 1 mg per pound (2.2 mg/kg) per day. Possible cross-sensitivity with other alkylating agents can occur. low amount of sodium in the blood. Dosages must be adjusted in accord with evidence of antitumor activity and/ or leukopenia. Find medical information for cyclophosphamide on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. Agents that are frequently co-administered with cyclophosphamide in high-dose chemotherapy regimens were tested for inhibition of the activation of cyclophosphamide in human liver microsomes. If you are a woman, do not use cyclophosphamide if you are pregnant. Drugs Diseases Why is Cyclophosphamide Prescribed? cyclophosphamide was approved for use in the united states in 1959 and its current indications include treatment of breast, head, neck, lung, cervix, testis and ovarian cancer, acute and chronic lymphocytic leukemia, hodgkin's and non-hodgkin's lymphoma, malignant histiocytosis, multiple myeloma, soft tissue sarcoma, mycosis fungoides, For cancer treatment, cyclophosphamide is dosed at 0.5 to 1 mg per pound (1 to 2 mg/kg) once daily. Cyclophosphamide metabolism demonstrates . Breast cancer. Cyclophosphamide (containing cyclophosphamide) reconstituted in water is hypotonic and should not be injected directly. You can have cyclophosphamide on its own, or in combination with other chemotherapy drugs. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus. Cyclophosphamide side effects (more detail) Liver diseaseThe effect of cyclophosphamide may be decreased. The dosage and schedule are determined by the person . 10 to 20 : 75-100% of normal dose depending on clinical indication and local protocol; 10 : 50-100% of normal dose depending on clinical indication and local . (a) Hodgkin lymphoma These patients often present with impaired renal function or even end-stage renal failure. Showing results for cyclophosphamide-drug- General principles of the use of cyclophosphamide in rheumatic diseases excretion of cyclophosphamide (CYC) are important issues related to its toxicity. These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells. what is DOSE Cyclophosphamide IN RENAL IMPAIRMENT , what IMPORTANT DRUG INTERACTIONS Cyclophosphamide,CLINICAL USE Cyclophosphamide , for what can Cyclophosphamide used for . Chronic lymphocytic leukemia (CLL). Cyclophosphamide (CYC) is an alkylating agent that was introduced into clinical practice as a chemotherapeutic agent but has also been used to treat a number of systemic autoimmune diseases. General principles of the use of cyclophosphamide in rheumatic diseases. Oral dosage Adults, Adolescents, and Children 1 to 5 mg/kg orally daily for both initial and maintenance dosing. leukemias: chronic lymphocytic leukemia, chronic . cyclophosphamide have been observed in patients with renal failure, increased clinical toxicity in such patients has not been demonstrated. Cyclophosphamide often causes nausea, vomiting, and loss of appetite. When cyclophosphamide is included in combined cytotoxic regimens, it may be necessary to reduce the Dosages must be adjusted in accord with evidence of antitumor activity and/or leukopenia. Drug Formulary information is intended for use by healthcare professionals. Cyclophosphamide is type of drug known as a disease-modifying anti-rheumatic drug (DMARD). . The Based on the recent Plasma Exchange and Glucocorticoids for the Treatment of ANCA-Associated Vasculitis (PEXIVAS) trial, a lower dosing of corticosteroids can be used. It is given orally or intravenously. Home; . Cyclophosphamide is inactive until metabolized by the liver. Other Name (s): Procytox. How cyclophosphamide works. Oral doses should be taken whole (not crushed, chewed, or broken) and with food in order to decrease nausea. Very bad and sometimes deadly liver problems have happened with this medicine (cyclophosphamide tablets). 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